NMR Spectroscopist / Scientific Associate II, Structural Chemistry - Novartis - Emeryville, CA, USA

From NMR Wiki

posted: June 9 2010

Novartis Institue of Biometical Research is looking for an NMR Spectroscopist.

About Novartis Institute of Biomedical Research

At Novartis Institutes for BioMedical Research (“NIBR”), the global research organization of Novartis, we are committed to discovering innovative medicines to cure disease and improve human health. By hiring the best academic, biotech, and pharmaceutical trained scientists, we have fostered and atmosphere for drug discovery where innovation is rewarded. It is ultimately the talent of the individual that determines our success, while our state-of-the-art technologies and resources enable these ideas to be realized.

NIBR has sites in Cambridge, Massachusetts; Emeryville, CA; Basel, Switzerland; Horsham, UK; and Shanghai, China. Our Emeryville location focuses on early drug discovery efforts for the Oncology Disease Area and offers a variety of positions in Biology, Chemistry, and functions such as Technology, Patents, Research Sciences and other areas that support our scientific resources.

About Structural Chemistry: The NIBR Emeryville Structural Chemistry group is responsible for actively pursuing the structures of macromolecular drug targets either as apo-proteins or in complex with lead compounds to help guide structure-based drug design, and actively participates in the drug discovery process. The group also provides biophysics and solutions studies support for drug discovery projects.

About the position

The successful candidate will be an integral member of drug discovery teams and will assist in the execution of receptor-ligand interaction studies by biophysical methods.
He or she will work closely with the scientists in protein biochemistry, computational chemistry, medicinal chemistry, and protein crystallography in providing support for structure-based drug design.
He or she will provide hands-on NMR sample preparation, as well as NMR data acquisition and processing, focused on assessing ligand-binding and analyzing the solution structures of proteins and protein:ligand complexes.
The candidate will help to establish an in-house NMR lab consisting of a 600 MHz spectrometer with associated computing and robotics.

The ideal candidate will have

A B.A. or M.S. or equivalent in Biochemistry, Chemistry, or Molecular Biology
At least 3 years (M.S.) or 5 years (B.A.) of work experience with demonstrated success in biophysical techniques
Experience in preparation of biomolecular samples for NMR data collection, as well as data collection as applied to ligand-based studies
A background in protein biochemistry and biophysical characterization of protein:ligand interaction, particularly ITC, DSC, and surface plasmon resonance
Experience in protein biochemistry and fragment-based screening is desirable
Strong communication skills
The ability to work in large, multidisciplinary drug discovery teams