NMR spectroscopists - Conformetrix Ltd., Manchester, UK

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Date posted: Oct 10, 2009
Position: Permanent contract
Location: Manchester city centre, UK
Application Deadline: 20th November 2009
Salary: £20,000 - £35,000 GBP / annum + potential for share options, dependent on experience


About the company

Conformetrix is a rapidly growing biotechnology company with a focus on ligand-based drug discovery. We are currently looking to recruit solution-state NMR spectroscopists with strong chemistry backgrounds to join our successful R&D team.

The chief activity is the 4D-structure (3D + conformational preferences) determination of small flexible molecules from NMR data using Conformetrix’s proprietary software tools. These structures provide the crucial structural data that enables truly rational ligand-based drug design to be realised, both for our in-house discovery programs and for our clients. Problem solving and an analytical mindset are very much required in this role, as is a willingness to work in a small multidisciplinary team.

The successful candidate(s) will be expected to have the ability to deliver high quality and precise results to tight deadlines with minimal supervision, and possess strong analytical and communication skills.

Main activities

1. Determination of the 4D-structures of small flexible molecules from NMR data, which involves:

  • NMR sample preparation
  • Recording and processing of NMR spectra
  • Analysis using Conformetrix’s proprietary software tools

2. Using the 4D-structures with the R&D team to identify and improve hit and lead drug molecules in our in-house discovery programs

3. Innovation of new protocols and methodologies for structure determination and analysis

4. Preparation of written reports and technical documentation packages on projects under guidance of supervisor

Experience requirements

  • Degree or equivalent in Chemistry (or Chemistry-based subject) is essential
  • Ph.D. in solution-state NMR is also essential, preferably with experience of small (<2000 Da) organic molecules.
  • Good computer literacy is essential. In particular, familiarity with Unix and molecular visualisation software would be advantageous.
  • Experience of chemical shift assignment and (protein) structure calculations is desirable.
  • Practical experience of Bruker NMR equipment.

Additional key skills

  • Learn quickly and work independently with minimal supervision.
  • Good organisational and time management skills.
  • Flexible and able to change priorities at short notice.
  • Able to work under pressure and meet deadlines.
  • Excellent word-processing and presentation skills.
  • Fluent in English and able to communicate results effectively.

Key working relationships

  • CSO to agree program of work
  • CEO for training and professional development support
  • Liaising with all members of the R&D team
  • Liaise with R&D team and outside scientists to develop knowledge base and discuss ideas

Open To: Applicants must be eligible to work in the specified location Posted Date: 08/10/2009 Reference: C4X-NMR02

How to apply

If you are interested in applying for this role and feel that you have the appropriate experience, then please call Gordon Barker at 0161 606 7203 or email your CV in PDF format to: gordon.barker at conformetrix.com

Please take a look at our company website] for further information.

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