Postdoctoral position in NMR Structural Biology - Paris Descartes University, Paris, France

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posted: November 29 2009

12 month post-doctoral position in Structural Biology NMR is open in Paris Descartes University. Funding for the position is provided by the French National Agency of Research (ANR) for 1 year.

About the Team and the Project

The postdoctoral position is available from April 1, 2010 in the Paris Descartes University to characterize the interaction of new HIV-1 anti-integrase inhibitors with LEDGF-Integrase complex.

The candidate will join the NMR & Molecular modeling team of the laboratory of Chemical and Biochemical Pharmacology and Toxicology (UMR8601 CNRS), and be responsible for the development and structural analysis of HIV-1 integrase by high-resolution solution NMR and molecular modeling. The main approach will be to characterize the interaction by transfer-NMR experiments (STD, WaterLOGSY, ...) and to participate in the development of AuPosSOM software to classify molecules according to their contact pattern with the target of interest and 2D/3D QSAR modeling.

Candidate requirements

Applicants should have a Ph.D. in Biochemistry, Chemistry or related fields.

The candidate is expected to have a strong expertise in solution NMR with in-depth training in NMR receptor-ligand interaction, protein structures and dynamics, and drug-protein interactions. Familiarity with biochemistry, biophysics is desirable. Experience with molecular modeling (docking, virtual screening, python language) would be a big plus.

How to apply

For any queries about the lab and research projects, please contact Gildas Bertho by e-mail: gildas.bertho 'at"

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