Determination of relative stereochemistry
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This review article discusses use of 2,3JCH, 3JHH scalar couplings and 13C chemical shifts for assignment of relative stereochemistry of centers (marked in bold) in -CHX-CHY- and -CHX-CH2-CHY- hydrocarbon fragments, where X and Y are polar substituents.
2JCH couplings are useful in fragments CYH-CHX where substituent X is polar (where coupling between atoms marked in bold is observed).
Bifulco, G., Dambruoso, P., Gomez-Paloma, L., Riccio, R.. Determination of Relative Configuration in Organic Compounds by NMR Spectroscopy and Computational Methods
