From NMR Wiki
Saturation transfer difference spectroscopy allows to detect transient binding of small molecule ligands to macromolecular receptors. Receptor species include proteins - free in solution or immobilized, whole virus particles, etc.
References
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Meyer, B and Peters, T. NMR Spectroscopy Techniques for Screening and Identifying Ligand Binding to Protein Receptors. Angewandte Chemie International Edition 42(8):864--890, 2003. BibTeX [meyer03]
