WEFT - water eliminated fourier transform

From NMR Wiki

This experiment[1] works for molecules whose T₁ relaxation time is shorter than T₁ relaxation time of water.

To achieve water suppression, t_n is selected so that the Z magnetization of water is zero at the moment the 90^o pulse is applied. During the same time Z magnetization of the molecule of interest has a chance to fully relax to equilibrium. Both T and t_n are around 6 s, but should be optimized.

The article[1] also describes ways of incorporating WEFT into experiments for determination of T₁ and T₂ relaxation times of macromolecular samples in water.

References

1. Patt, SL and Sykes, BD. Water eliminated Fourier transform NMR spectroscopy. The Journal of Chemical Physics 56:3182, 1972. BibTeX [weft]