PhD studentship in NMR methods development - University of Nantes, France

From NMR Wiki

posted: April 10 2010

The CEISAM laboratory (UMR 6230, CNRS-University of Nantes), located in Nantes, France, is recruiting a highly motivated student for a 3-years PhD position. Subject: "Methodological developments in ultrafast 2D NMR for metabolic studies". Financial support from the French Ministry of Research or from the French National Research Agency (ANR) is expected.

About the project

2D NMR is a powerful analytical tool, widely used in chemistry, biochemistry or for biomedical applications. However, its use for quantitative studies is limited by long acquisition durations that characterize this methodology. A so-called “ultrafast” methodology was recently proposed (1) to record a full 2D spectrum in a single scan and in a fraction of a second. Our group is one of the world’s leading teams for developing this novel and promising methodology. We have recently shown that it could be used for quantitative purposes with an excellent precision (2). However, further development is necessary to make it suitable for studying complex metabolic mixtures.

The recruited candidate will develop ultrafast 2D NMR methods to improve their performances for studying complex samples. The methodology will be evaluated for a variety of applications such as chemical or microbiological kinetic studies, and metabolic applications. The student will be encouraged to present his/her results in national and international conferences.

Candidate requirements

Prospective PhD candidates must hold a Master degree in Physical Chemistry, Chemical Physics or Analytical Chemistry and have solid knowledge in NMR. A previous experience in experimental NMR and/or programming will be a plus. The candidates should be highly motivated and show an aptitude to work independently.

How to apply

Please contact:

Patrick Giraudeau (patrick.giraudeau@univ-nantes.fr)
Serge Akoka (serge.akoka@univ-nantes.fr)
CEISAM, Bât. 9, Faculté des Sciences et des Techniques – BP 92208
2 rue de la Houssinière 44322 Nantes Cedex 3
FRANCE
Tel : 02.51.12.57.07 / 02.51.12.57.09

References

1. Giraudeau, P and Remaud, GS and Akoka, S. Evaluation of ultrafast 2D NMR for quantitative analysis.. Analytical chemistry 81(1):479, 2009. BibTeX [ac2009]

2. Frydman, L and Scherf, T and Lupulescu, A. The acquisition of multidimensional NMR spectra within a single scan. Proceedings of the National Academy of Sciences of the United States of America 99(25):15858, 2002. BibTeX [fryman02]