Postdoc in biomolecular solid state NMR - Hospital for Sick Children/University of Toronto, Toronto, Ontario

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posted: November 23 2009

Postdoctoral positions in biomolecular solid state NMR are available at The Hospital for Sick Children.

Projects focus on structure determination and dynamic characterization of protein and peptide assemblies by solid state NMR, with an emphasis on systems relevant to human health and disease. Ongoing projects include structural studies of oligomeric states of mammalian prion proteins, membrane interactions of amyloid peptides, and structure determination of integral membrane complexes that play a key role in HIV-1 infection. These projects are highly multidisciplinary in nature, and will provide candidates with the opportunity to learn a broad range of biophysical techniques, in addition to NMR, and to collaborate with a number of other research groups.

About the Laboratory and Facilities

The laboratory is located within the Molecular Structure and Function Program at the Hospital for Sick Children and the Department of Biochemistry at the University of Toronto, providing a diverse and stimulating research environment. We are fully equipped for cloning, mutagenesis, protein expression and purification, with access to peptide synthesis, computational biology facilities and full-time use of a 500 MHz spectrometer for solids MAS and static experiments. In addition, access to the national 900MHz NMR facility in Ottawa is also available for most projects.

Candidate requirements

Highly motivated candidates are sought, who must possess a PhD with a strong track record of scientific productivity, and who should have extensive experience in either biological NMR (solution or solid state) or protein biophysics and structure determination. The start date for this position is negotiable, but is available immediately.

How to apply

Qualified candidates should send a complete CV to ssharpe at, and arrange for 3 letters of reference to be sent to:

Simon Sharpe
Scientist, Molecular Structure and Function Programme The Hospital for Sick Children
Assistant Professor, Dept. of Biochemistry, University of Toronto
555 University Ave, Toronto, Ontario, Canada M5G 1X8

email ssharpe “at”

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