Ph.D. and Postdoctoral positions in Bio-Molecular NMR - Grenoble, France

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data posted: December 17, 2009

Several Ph.D. and Postdoctoral positions are available in the NMR laboratory of the Structural Biology Institute in Grenoble (France). Positions are available on the following topics:

  • Development and application of Fast multidimensional NMR methods for the study of molecular kinetics and excited-state conformations.
  • Studies of intact Bacterial Cell walls using solid- and-liquid state NMR.
  • NMR studies of membrane proteins.
  • Development of Isotopic labeling and NMR spectroscopy methods for the study of high molecular weight protein assemblies.
  • Study of structure, function, and dynamics of biomolecules involved in Antibiotic resistance and virulence.
  • Real-time NMR investigation of folding and mechanisms of biological Nanomachines.

Equipment and facilities

The laboratory hosts three NMR spectrometers equipped with cryogenic probes (600 MHz and 800 MHz) and with a solid state MAS equipment (600 MHz). It has access to the nearby 1 GHz NMR spectrometer of the European high field NMR centre in Lyon. Applicants will also have access to a fully equipped wetlab for isotopically labeled NMR sample preparation.

Grenoble is a pleasant city situated in the heart of the French alps, and has one of Europe’s most vibrant structural biology communities centred around the European Synchroton Radiation Facility (ESRF), the Laue Langevin Institute (ILL), the Structural Biology Institute (IBS) and the EMBL Grenoble Out-Station.


Competitive salary (based on previous research experience) is offered with health insurance, retirement plan, and language training allowance.

How to apply

Interested candidates should forward a Curriculum Vitae, and electronic and postal addresses of potential references via e-mail to: diff-jobs-nmr at

NMR Laboratory
Institut de Biologie Structurale
41 rue Jules Horowitz
38027 GRENOBLE Cedex 1

Selected publications

  1. Amero, C and Schanda, P and Dura, MA and Ayala, I and Marion, D and Franzetti, B and Brutscher, B and Boisbouvier, J. Fast Two-Dimensional NMR Spectroscopy of High Molecular Weight Protein Assemblies.. Journal of the American Chemical Society , 2009. BibTeX [amero09]
  2. Bersch, B and Favier, A and Schanda, P and van Aelst, S and Vallaeys, T and Coves, J and Mergeay, M and Wattiez, R. Molecular structure and metal-binding properties of the periplasmic CopK protein expressed in Cupriavidus metallidurans CH34 during copper challenge. Journal of Molecular Biology 380(2):386--403, 2008. BibTeX [bersh08]

  3. Boudet, J and Duval, V and Van Melckebeke, H and Blackledge, M and Amoroso, A and Joris, B and Simorre, JP. Conformational and thermodynamic changes of the repressor/DNA operator complex upon monomerization shed new light on regulation mechanisms of bacterial resistance against β-lactam antibiotics. Nucleic Acids Research 35(13):4384, 2007. BibTeX [boudet07]

  4. Farjon, J and Boisbouvier, J and Schanda, P and Pardi, A and Simorre, JP and Brutscher, B. Longitudinal-Relaxation-Enhanced NMR Experiments for the Study of Nucleic Acids in Solution.. Journal of the American Chemical Society , 2009. BibTeX [farjon09]

  5. Gal, M and Schanda, P and Brutscher, B and Frydman, L. UltraSOFAST HMQC NMR and the repetitive acquisition of 2D protein spectra at Hz rates. J Am Chem Soc 129(5):1372--1377, 2007. BibTeX [gal07]

  6. Kern, T and Hediger, S and Müller, P and Giustini, C and Joris, B and Bougault, C and Vollmer, W and Simorre, JP. Toward the Characterization of Peptidoglycan Structure and Protein- Peptidoglycan Interactions by Solid-State NMR Spectroscopy. Journal of the American Chemical Society 130(17):5618--5619, 2008. BibTeX [kern08]

  7. Lescop Ewen, IBS and CEA, SP and CNRS, RR. Automated spectral compression for fast multidimensional NMR and increased time resolution in real-time NMR spectroscopy. Journal of the American Chemical Society 129(10):2756--2757, 2007. BibTeX [lescop07]

  8. Rasia, R and Noirclerc-Savoye, M and Bologna, N and Gallet, B and Plevin, MJ and Blanchard, L and Palatnik, J and Brutscher, B and Vernet, T and Boisbouvier, J. Parallel screening and optimization of protein constructs for structural studies. Protein Science 18(2):434--439, 2009. BibTeX [rasia09]

  9. Schanda, P and Forge, V and Brutscher, B. Protein folding and unfolding studied at atomic resolution by fast two-dimensional NMR spectroscopy. Proceedings of the National Academy of Sciences 104(27):11257, 2007. BibTeX [schanda07]

  10. Sounier Remy, IBS and Laurence, B and Wu, Z. High-accuracy distance measurement between remote methyls in specifically protonated proteins. Journal of the American Chemical Society 129(3):472--473, 2007. BibTeX [sounier07]

  11. Tarendeau, F and Boudet, J and Guilligay, D and Mas, PJ and Bougault, CM and Boulo, S and Baudin, F and Ruigrok, RW and Daigle, N and Ellenberg, J and others. Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit. Nature Structural and Molecular Biology 14(3):229, 2007. BibTeX [tandreau07]

  12. Van Melckebeke, H and Devany, M and Di Primo, C and Beaurain, F and Toulm{\'e}, JJ and Bryce, DL and Boisbouvier, J. Liquid-crystal NMR structure of HIV TAR RNA bound to its SELEX RNA aptamer reveals the origins of the high stability of the complex. Proceedings of the National Academy of Sciences 105(27):9210, 2008. BibTeX [vanmel08]

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