Senior NMR scientist - Beatson Inst. for Cancer Research, Glasgow, UK

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posted: Oct 14, 2009
application deadline: Oct 31, 2009

The Beatson Institute for Cancer Research, located in Glasgow, United Kingdom, is seeking a highly motivated and talented NMR scientist who will drive the primary NMR fragment based screening. The individual will work closely with colleagues within the Structural Biology group as well as chemists and biologists from the wider team. The individual will be integral in establishing fragment screening technology as well as other NMR methodology on the 600MHz instrument. In addition general support for the small molecule analytical NMR on the 400MHz machine will be required.

For a suitably qualified, industry experienced candidate there is the possibility that you can also fulfil the role of Head of Structural Biology. Reporting to the Head of Drug Discovery, you along with the Heads of Chemistry and Biology will have a fundamental role in directing the overall strategy of the programme. In addition you will be responsible for the management of a team operating across x-ray crystallography, surface plasmon resonance (SPR) and protein production.

About the Beatson Drug Discovery programme

The Beatson Drug Discovery Programme will become established as an Industry Standard Unit at the cutting edge of drug discovery. Exploiting the basic biology strengths within the Beatson Institute and wider CR-UK network the programme will target some of the most exciting and challenging cancer targets. Central to our strategy is Fragment Based Drug Discovery methods and we intend to use NMR as a primary tool for fragment based hit identification. To that end we have recently agreed to purchase a state-of-the-art 600Mhz NMR with cold probe and a 96-position sample changer from Varian. In addition, as support for day-to-day chemistry/small molecule NMR, a 400MHz instrument with 96-position sample changer has also been purchased.

Candidate requirements

We are looking for an individual with a Ph.D. in NMR based science and significant industrial or post-doctorial experience. A background in macromolecular NMR is desired and some experience with small molecule NMR would be an advantage.

How to apply

Please send expressions of interest to Dr. Martin Drysdale, Head, Beatson Drug Discovery Programme at m.drysdale at by 31st October 2009.

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